USC-OGP 2-DE database Two-dimensional polyacrylamide gel electrophoresis database

USC-OGP 2-DE database  Search by                Maps             Select Remote Interfaces [All Interfaces] SWISS-2DPAGE World-2DPAGE Portal World-2DPAGE Repository Exclude local DBs has only effect if a remote interface is selected

Searching in 'USC-OGP 2-DE database' for entry matching: O43283 USC-OGP 2-DE database:  O43283 O43283 General information about the entry View entry in simple text format Entry name M3K13_HUMAN Primary accession number O43283 integrated into USC-OGP 2-DE database on  January 17, 2017 (release 1) 2D Annotations were last modified on January 17, 2017 (version 1) General Annotations were last modified on  April 5, 2017 (version 2) Name and origin of the protein Description RecName: Full=Mitogen-activated protein kinase kinase kinase 13; EC=2.7.11.25; AltName: Full=Leucine zipper-bearing kinase; AltName: Full=Mixed lineage kinase; Short=MLK;. Gene name Name=MAP3K13 {ECO:0000312|HGNC:HGNC:6852} Synonyms=LZK {ECO:0000312|EMBL:BAA24817.1} Annotated species Homo sapiens (Human) [TaxID: 9606] Taxonomy Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo. References [1]   2D GEL CHARACTERIZATION Author 1., Author 2. Submitted (Mar-2011) to Current 2D PAGE maps for identified proteins How to interpret a protein UVEAL_MELANOMA_3-10 {UVEAL MELANOMA 3-10} Homo sapiens (Human)   map experimental info   UVEAL_MELANOMA_3-10 MAP LOCATIONS: SPOT OGP-1129: pI=5.33; Mw=66847 Cross-references UniProtKB/Swiss-Prot O43283; M3K13_HUMAN. 2D PAGE maps for identified proteins How to interpret a protein map You may obtain an estimated location of the protein on various 2D PAGE maps, provided the whole amino acid sequence is known. The estimation is obtained according to the computed protein's pI and Mw. Warning 1: the displayed region reflects an area around the theoretical pI and molecular weight of the protein and is only provided for the user's information. It should be used with caution, as the experimental and theoretical positions of a protein may differ significantly. Warning 2: the 2D PAGE map is built on demand. This may take some few seconds to be computed. External data extracted from UniProtKB/Swiss-Prot Extracted from UniProtKB/Swiss-Prot, release: 0.0 Entry name M3K13_HUMAN Primary accession number O43283 Secondary accession number(s) B2R6U2 B4DLE3 B4DMV2 B4DZJ4 D3DNU1 Q05BY6 Q15450 Q2NKN3 Sequence was last modified on  June 1, 1998 (version 1) Annotations were last modified on  March 15, 2017 (version 148) Name and origin of the protein Description RecName: Full=Mitogen-activated protein kinase kinase kinase 13; EC=2.7.11.25; AltName: Full=Leucine zipper-bearing kinase; AltName: Full=Mixed lineage kinase; Short=MLK; Gene name Name=MAP3K13 {ECO:0000312|HGNC:HGNC:6852} Synonyms=LZK {ECO:0000312|EMBL:BAA24817.1} Encoded on Name=MAP3K13 {ECO:0000312|HGNC:HGNC:6852}; Synonyms=LZK {ECO:0000312|EMBL:BAA24817.1 Keywords Alternative splicing; ATP-binding; Complete proteome; Cytoplasm; Kinase; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase. Copyright Copyrighted by the UniProt Consortium, see http://www.uniprot.org/help/license. Distributed under the Creative Commons Attribution-NoDerivs License Cross-references EMBL AB001872; BAA24817.1; -; mRNA EMBL AK296961; BAG59505.1; ALT_SEQ; mRNA EMBL AK297646; BAG60014.1; -; mRNA EMBL AK302951; BAG64106.1; -; mRNA EMBL AK312714; BAG35589.1; -; mRNA EMBL AC099661; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC128680; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL AC132516; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL CH471052; EAW78224.1; -; Genomic_DNA EMBL CH471052; EAW78225.1; -; Genomic_DNA EMBL BC031677; AAH31677.1; -; mRNA EMBL BC111726; AAI11727.1; ALT_SEQ; mRNA EMBL Z25428; CAA80915.1; -; mRNA CCDS CCDS3270.1; -. [O43283-1]; . CCDS CCDS56298.1; -. [O43283-5]; . PIR I38218; I38218; . RefSeq NP_001229243.1; NM_001242314.1. [O43283-1]; . RefSeq NP_001229246.1; NM_001242317.1. [O43283-5]; . RefSeq NP_004712.1; NM_004721.4. [O43283-1]; . RefSeq XP_011511612.1; XM_011513310.2. [O43283-1]; . RefSeq XP_016862945.1; XM_017007456.1. [O43283-1]; . UniGene Hs.591306; -; . UniGene Hs.634586; -; . ProteinModelPortal O43283; -; . SMR O43283; -; . BioGrid 114614; 12; . IntAct O43283; 3; . MINT MINT-158088; -; . STRING 9606.ENSP00000265026; -; . BindingDB O43283; -; . ChEMBL CHEMBL1163124; -; . GuidetoPHARMACOLOGY 2073; -; . iPTMnet O43283; -; . PhosphoSitePlus O43283; -; . BioMuta MAP3K13; -; . PaxDb O43283; -; . PeptideAtlas O43283; -; . PRIDE O43283; -; . Ensembl ENST00000265026; ENSP00000265026; ENSG00000073803. [O43283-1]; . Ensembl ENST00000424227; ENSP00000399910; ENSG00000073803. [O43283-1]; . Ensembl ENST00000433092; ENSP00000389798; ENSG00000073803. [O43283-6]; . Ensembl ENST00000438053; ENSP00000403561; ENSG00000073803. [O43283-3]; . Ensembl ENST00000443863; ENSP00000409325; ENSG00000073803. [O43283-4]; . Ensembl ENST00000446828; ENSP00000411483; ENSG00000073803. [O43283-5]; . GeneID 9175; -; . KEGG hsa:9175; -; . UCSC uc003fph.5; human. [O43283-1]; . CTD 9175; -; . DisGeNET 9175; -; . GeneCards MAP3K13; -; . HGNC HGNC:6852; MAP3K13; . HPA HPA016497; -; . HPA HPA036691; -; . HPA HPA036692; -; . MIM 604915; gene; . neXtProt NX_O43283; -; . OpenTargets ENSG00000073803; -; . PharmGKB PA30596; -; . eggNOG KOG4721; Eukaryota; . eggNOG ENOG410YKX2; LUCA; . GeneTree ENSGT00760000118807; -; . HOVERGEN HBG052383; -; . InParanoid O43283; -; . KO K04422; -; . OMA HRRGNSR; -; . OrthoDB EOG091G0905; -; . PhylomeDB O43283; -; . TreeFam TF105119; -; . SignaLink O43283; -; . SIGNOR O43283; -; . ChiTaRS MAP3K13; human; . GeneWiki MAP3K13; -; . GenomeRNAi 9175; -; . PRO PR:O43283; -; . Proteomes UP000005640; Chromosome 3; . Bgee ENSG00000073803; -; . CleanEx HS_MAP3K13; -; . ExpressionAtlas O43283; baseline and differential; . Genevisible O43283; HS; . GO GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell; . GO GO:0016020; C:membrane; IDA:UniProtKB; . GO GO:0005524; F:ATP binding; IEA:UniProtKB-KW; . GO GO:0042802; F:identical protein binding; IPI:IntAct; . GO GO:0004709; F:MAP kinase kinase kinase activity; IDA:UniProtKB; . GO GO:0046872; F:metal ion binding; IEA:UniProtKB-KW; . GO GO:0042803; F:protein homodimerization activity; IDA:UniProtKB; . GO GO:0019901; F:protein kinase binding; ISS:UniProtKB; . GO GO:0004674; F:protein serine/threonine kinase activity; IDA:UniProtKB; . GO GO:0000186; P:activation of MAPKK activity; IDA:UniProtKB; . GO GO:0007254; P:JNK cascade; IDA:UniProtKB; . GO GO:0051092; P:positive regulation of NF-kappaB transcription factor activity; IDA:UniProtKB; . GO GO:0046777; P:protein autophosphorylation; IDA:UniProtKB; . GO GO:0006468; P:protein phosphorylation; IDA:UniProtKB; . InterPro IPR011009; Kinase-like_dom; . InterPro IPR017419; MAP3K12_MAP3K13; . InterPro IPR027258; MAPKKK13; . InterPro IPR000719; Prot_kinase_dom; . InterPro IPR001245; Ser-Thr/Tyr_kinase_cat_dom; . InterPro IPR008271; Ser/Thr_kinase_AS; . PANTHER PTHR23257:SF560; PTHR23257:SF560; 1; . Pfam PF07714; Pkinase_Tyr; 1; . PIRSF PIRSF038165; MAPKKK12_MAPKKK13; 1; . PIRSF PIRSF500742; MAPKKK13; 1; . PRINTS PR00109; TYRKINASE; . SMART SM00220; S_TKc; 1; . SUPFAM SSF56112; SSF56112; 1; . PROSITE PS50011; PROTEIN_KINASE_DOM; 1; . PROSITE PS00108; PROTEIN_KINASE_ST; 1; .

Gateways to other related servers

• The World-2DPAGE Constellation - Entry point to the world-wide 2-DPAGE resources.
• World-2DPAGE Repository - A public repository for gel-based proteomics data linked to protein identification published in the literature.
• World-2DPAGE Portal - A dynamic portal to query simultaneously world-wide gel-based proteomics databases.
• SWISS-2DPAGE - The Geneva Two-dimensional polyacrylamide gel electrophoresis database.
• ExPASy - The resources web server of the Swiss Institute of Bioinformatics

[Home]